semaglutide spleen impacts skeletal muscle to a similar extent as caloric restriction in mice with diet‐induced obesity - Jeromson - The Journal of Physiology Ozempic: What Does It Do

doi: 10.1001/jama.2023.24945 Sodhi M, et al

Looking from 2023 to 2024, the latest year of data available, prescriptions and gross spending for Wegovy (first approved for obesity in 2021, approved for cardiovascular disease in 2024) and Mounjaro (approved for type 2 diabetes in 2022) more than doubled, and prescriptions and gross spending for Zepbound (first approved for obesity in 2023, approved for sleep apnea in 2024) increased more than fivefold

This highlights the limited role that GLP-1RAs play in lipid management, suggesting that additional lipid-lowering therapies may be necessary for comprehensive metabolic control 27,28,29

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Metabolism naturally slows with age, and body composition shifts toward relatively less muscle and more fat unless we actively resist it